| Active Players |
| 58 | Barber, Austin | OT | 05/20/2003 | 23 | 6' 07" | 320 | Florida | CLE | 26 03 086 | R |
| 97 | Barnett, Derek | DE | 06/25/1996 | 30 | 6' 03" | 260 | Tennessee | PHI | 17 01 014 | 10 |
| 29 | Blackmon, Mekhi | CB | 03/18/1999 | 27 | 5' 11" | 178 | USC | MIN | 23 03 102 | 4 |
| 13 | Bojorquez, Corey | PT | 09/13/1996 | 30 | 6' 00" | 217 | New Mexico | NE FA | 18 CFA | 9 |
| 0 | Bond, Isaiah | WR | 03/15/2004 | 22 | 5' 11" | 180 | Texas | CLE FA | 25 CFA | 2 |
| 12 | Boston, Denzel | WR | 12/06/2003 | 22 | 6' 04" | 215 | Washington | CLE | 26 02 039 | R |
| 52 | Brailsford, Parker | C | 10/20/2003 | 22 | 6' 02" | 290 | Alabama | CLE | 26 05 146 | R |
| 34 | Burton, Michael | FB | 02/01/1992 | 34 | 6' 00" | 247 | Rutgers | DET | 15 05 168 | 12 |
| 7 | Campbell, Tyson | CB | 03/17/2000 | 26 | 6' 01" | 195 | Georgia | JAX | 21 02 033 | 6 |
| 96 | Collins, Maliek | DT | 04/08/1995 | 31 | 6' 02" | 310 | Nebraska | DAL | 16 03 067 | 11 |
| 1 | Concepcion, KC | WR | 09/24/2004 | 21 | 5' 11" | 190 | Texas A&M | CLE | 26 01 024 | R |
| 11 | Corley, Malachi | WR | 03/21/2002 | 24 | 5' 11" | 215 | Western Kentucky | NYJ | 24 03 065 | 3 |
| 9 | Delpit, Grant | S | 09/20/1998 | 27 | 6' 02" | 208 | LSU | CLE | 20 02 044 | 7 |
| 44 | Fannin Jr., Harold | TE | 07/20/2004 | 22 | 6' 03" | 241 | Bowling Green | CLE | 25 03 067 | 2 |
| 55 | Fano, Spencer | OT | 11/04/2004 | 21 | 6' 05" | 315 | Utah | CLE | 26 01 009 | R |
| 94 | Graham, Mason | DT | 09/02/2003 | 23 | 6' 03" | 315 | Michigan | CLE | 25 01 005 | 2 |
| 15 | Green, Taylen | QB | 10/18/2002 | 23 | 6' 06" | 230 | Arkansas | CLE | 26 06 182 | R |
| 51 | Hall Jr., Mike | DT | 06/13/2003 | 23 | 6' 03" | 300 | Ohio State | CLE | 24 02 054 | 3 |
| 26 | Harden, Myles | CB | 12/13/2001 | 24 | 5' 11" | 195 | South Dakota | CLE | 24 07 227 | 3 |
| 33 | Hickman, Ronnie | S | 10/11/2001 | 24 | 6' 01" | 209 | Ohio State | CLE FA | 23 CFA | 4 |
| 71 | Howard, Tytus | OT | 05/23/1996 | 30 | 6' 05" | 320 | Alabama State | HOU | 19 01 023 | 8 |
| 98 | Huntington, Adin | DT | 03/18/2002 | 24 | 6' 01" | 281 | Tulane | CLE FA | 25 CFA | 2 |
| 20 | Igbinoghene, Noah | CB | 11/27/1999 | 26 | 5' 10" | 197 | Auburn | MIA | 20 01 030 | 7 |
| 17 | Jefferson, Justin | LB | 03/20/2003 | 23 | 6' 00" | 223 | Alabama | CLE | 26 05 149 | R |
| 74 | Jenkins, Elgton | C | 12/26/1995 | 30 | 6' 04" | 310 | Mississippi State | GB | 19 02 044 | 8 |
| 78 | Jenkins, Teven | OG | 03/03/1998 | 28 | 6' 05" | 321 | Oklahoma State | CHI | 21 02 039 | 6 |
| 3 | Jeudy, Jerry | WR | 04/24/1999 | 27 | 6' 01" | 195 | Alabama | DEN | 20 01 015 | 7 |
| 77 | Johnson, Zion | OG | 11/18/1999 | 26 | 6' 03" | 315 | Boston College | LAC | 22 01 017 | 5 |
| 79 | Jones, Dawand | OT | 08/06/2001 | 25 | 6' 08" | 374 | Ohio State | CLE | 23 04 111 | 4 |
| 10 | Judkins, Quinshon | RB | 10/29/2003 | 22 | 6' 00" | 221 | Ohio State | CLE | 25 02 036 | 2 |
| 42 | Mascarenas-Arnold, Easton | LB | 09/13/2002 | 24 | 5' 11" | 227 | USC | CLE FA | 25 CFA | 2 |
| 57 | McGuire, Isaiah | DE | 07/27/2001 | 25 | 6' 04" | 268 | Missouri | CLE | 23 04 126 | 4 |
| 31 | McMillon, Donovan | S | 06/18/2002 | 24 | 6' 01" | 203 | Pittsburgh | CLE FA | 25 CFA | 2 |
| 28 | McNeil-Warren, Emmanuel | S | 01/08/2004 | 22 | 6' 03" | 210 | Toledo | CLE | 26 02 058 | R |
| 35 | Pride Jr., Toriano | CB | 12/18/2003 | 22 | 5' 10" | 185 | Missouri | BUF | 26 07 220 | R |
| 59 | Reid, Winston | LB | 08/03/1999 | 27 | 6' 00" | 225 | Weber State | CLE FA | 24 CFA | 3 |
| 48 | Ryan, Carsen | TE | 08/21/2003 | 23 | 6' 03" | 255 | BYU | CLE | 26 07 248 | R |
| 22 | Sampson, Dylan | RB | 09/14/2004 | 21 | 5' 08" | 200 | Tennessee | CLE | 25 04 126 | 2 |
| 23 | Sanders, Raheim | RB | 06/08/2003 | 23 | 6' 00" | 230 | South Carolina | LAC FA | 25 CFA | 2 |
| 2 | Sanders, Shedeur | QB | 02/07/2002 | 24 | 6' 01" | 212 | Colorado | CLE | 25 05 144 | 2 |
| 49 | Schwesinger, Carson | LB | 02/24/2003 | 23 | 6' 02" | 242 | UCLA | CLE | 25 02 033 | 2 |
| 50 | Sunahara, Rex | LS | 10/09/1996 | 29 | 6' 06" | 242 | West Virginia | MIA FA | 20 CFA | 3 |
| 25 | Szmyt, Andre | PK | 09/26/1998 | 27 | 6' 00" | 200 | Syracuse | CHI FA | 23 CFA | 2 |
| 24 | Thomas, Daniel | S | 07/01/1998 | 28 | 5' 10" | 215 | Auburn | JAX | 20 05 157 | 7 |
| 8 | Verse, Jared | DE | 11/04/2000 | 25 | 6' 04" | 260 | Florida State | LAR | 24 01 019 | 3 |
| 16 | Wallace, Tylan | WR | 05/13/1999 | 27 | 5' 11" | 200 | Oklahoma State | BAL | 21 04 131 | 6 |
| 21 | Ward, Denzel | CB | 04/28/1997 | 29 | 5' 11" | 190 | Ohio State | CLE | 18 01 004 | 9 |
| 4 | Watson, Deshaun | QB | 09/14/1995 | 31 | 6' 02" | 223 | Clemson | HOU | 17 01 012 | 10 |
| 86 | Whiteheart, Blake | TE | 03/22/2000 | 26 | 6' 04" | 250 | Wake Forest | ARZ FA | 23 CFA | 4 |
| 5 | Williams, Quincy | LB | 08/28/1996 | 30 | 5' 11" | 230 | Murray State | JAX | 19 03 098 | 8 |
| 54 | Williams, Sam | DE | 03/31/1999 | 27 | 6' 04" | 260 | Mississippi | DAL | 22 02 056 | 5 |
| 56 | Wypler, Luke | C | 05/03/2001 | 25 | 6' 03" | 303 | Ohio State | CLE | 23 06 190 | 4 |
| 70 | Zinter, Zak | OG | 04/17/2001 | 25 | 6' 06" | 310 | Michigan | CLE | 24 03 085 | 3 |
| Practice Squad |
| 27 | Bryant, Myles | CB | 01/02/1998 | 28 | 5' 08" | 192 | Washington | NE FA | 20 CFA | 7 |
| 39 | Coats Jr., Michael | CB | 06/20/2001 | 25 | 5' 09" | 184 | West Virginia | CLE FA | 26 CFA | R |
| 99 | Fano, Logan | DE | 06/19/2002 | 24 | 6' 05" | 252 | Utah | CLE FA | 26 CFA | R |
| 92 | Kamara, Sam | DT | 12/21/1997 | 28 | 6' 01" | 272 | Stony Brook | CHI FA | 21 CFA | 4 |
| 72 | Leveston, KT | OT/OG | 10/28/1999 | 26 | 6' 04" | 335 | Kansas State | LAR | 24 07 254 | 3 |
| 69 | Logue, Zion | DT | 07/13/2001 | 25 | 6' 06" | 325 | Georgia | ATL | 24 06 197 | 1 |
| 38 | McLaughlin, Jaleel | RB | 09/13/2000 | 26 | 5' 08" | 187 | Youngstown State | DEN FA | 23 CFA | 4 |
| 88 | Oliver, Bryce | WR | 05/19/2000 | 26 | 6' 01" | 214 | Youngstown State | TEN FA | 24 CFA | 3 |
| 36 | Pahl, Wes | PT | 05/18/2002 | 24 | 6' 05" | 207 | Oklahoma State | CLE FA | 26 CFA | R |
| 38 | Ross, D'Angelo | CB | 10/29/1996 | 29 | 5' 08" | 190 | New Mexico | NE FA | 19 CFA | 5 |
| 84 | Swinson, Messiah | TE | 04/20/2000 | 26 | 6' 07" | 259 | Arizona State | GB FA | 24 CFA | 1 |
| 90 | Sydnor, Khordae | DE | 08/24/2003 | 23 | 6' 04" | 264 | Vanderbilt | CLE FA | 26 CFA | R |
| 30 | Washington, Zion | S | 02/16/2003 | 23 | 6' 01" | 208 | Boise State | CLE FA | 26 CFA | R |
| 40 | Watson, Nathaniel | LB | 09/01/2000 | 26 | 6' 02" | 233 | Mississippi State | CLE | 24 06 206 | 3 |
| 61 | Williams, Chris | DT | 06/16/1998 | 28 | 6' 02" | 298 | Wagner | IND FA | 20 CFA | 5 |
| 87 | Wilson, Kole | WR | 12/16/2003 | 22 | 5' 07" | 177 | Baylor | CLE FA | 26 CFA | R |
| Reserves |
| 66 | Bell, Travis | DT | 10/27/1998 | 27 | 6' 00" | 310 | Kennesaw State | CHI | 23 07 218 | 2 |
| 62 | Chatman, Elijah | DT | 12/05/2000 | 25 | 5' 11" | 278 | SMU | NYG FA | 24 CFA | 2 |
| 93 | Davis, Kalia | DT | 10/02/1998 | 27 | 6' 01" | 310 | Central Florida | SF | 22 06 220 | 5 |
| 6 | Gabriel, Dillon | QB | 12/28/2000 | 25 | 5' 11" | 205 | Oregon | CLE | 25 03 094 | 2 |
| 53 | Green, Kendrick | OG | 12/22/1998 | 27 | 6' 02" | 315 | Illinois | PIT | 21 03 087 | 5 |
| 37 | Mathis, Damarri | CB | 04/12/1999 | 27 | 5' 11" | 195 | Pittsburgh | DEN | 22 04 115 | 5 |
| 6 | Owusu-Koramoah, Jeremiah | LB | 11/04/1999 | 26 | 6' 01" | 221 | Notre Dame | CLE | 21 02 052 | 6 |
| 18 | Royer, Joe | TE | 02/25/2002 | 24 | 6' 05" | 250 | Cincinnati | CLE | 26 05 170 | R |
| 80 | Thrash, Jamari | WR | 12/19/2000 | 25 | 6' 00" | 190 | Louisville | CLE | 24 05 156 | 3 |
| 54 | Ulofoshio, Edefuan | LB | 01/23/2000 | 26 | 6' 00" | 240 | Washington | BUF | 24 05 160 | 2 |
| 91 | Wright, Alex | DE | 09/05/2000 | 26 | 6' 05" | 267 | UAB | CLE | 22 03 078 | 5 |