| Alford, Dee |  ATL | CB | UFA |  BUF |
| Allen, Kyle |  DET | QB | UFA | BUF |
| Anderson, Alec | BUF | OG | RFA | BUF |
| Bosa, Joey | BUF | ED | UFA | |
| Chubb, Bradley |  MIA | ED | CC | BUF |
| Cooks, Brandin | BUF | WR | UFA | |
| Corbett, Austin |  CAR | OG | UFA | BUF |
| Cushenberry, Lloyd |  TEN | C | CC | BUF |
| Danna, Mike |  KC | ED | CC | BUF |
| Davis, Gabe | BUF | WR | UFA | |
| Edwards, David | BUF | OG | UFA |  NO |
| Epenesa, A.J. | BUF | ED | UFA | |
| Flannigan-Fowles, Demetrius |  NYG | LB | UFA | BUF |
| Franklin Jr., Sam | BUF | S | UFA | BUF |
| Gardner-Johnson, C.J. |  CHI | S | UFA | BUF |
| Gilliam, Reggie | BUF | FB | UFA |  NE |
| Hamlin, Damar | BUF | S | UFA | BUF |
| Jackson, Dane | BUF | CB | CC | |
| Johnson, Taron | BUF | CB | Trade |  LV |
| Jones, DaQuan | BUF | DT | UFA | |
| Lewis, Cam | BUF | S | UFA | CHI |
| Mathis, Phidarian | BUF | DT | UFA | BUF |
| McGovern, Connor | BUF | C | UFA | BUF |
| Milano, Matt | BUF | LB | UFA | |
| Moore, DJ | CHI | WR | Trade | BUF |
| Ogunjobi, Larry | BUF | DT | UFA | |
| Phillips, Jordan | BUF | DT | UFA | |
| Poyer, Jordan | BUF | S | UFA | |
| Prater, Matt | BUF | PK | UFA | |
| Rapp, Taylor | BUF | S | CC | |
| Samuel, Curtis | BUF | WR | CC | |
| Savage, Darnell | BUF | S | UFA |  PIT |
| Spector, Baylon | BUF | LB | RFA | |
| Stone, Geno |  CIN | S | UFA | BUF |
| Thompson, Shaq | BUF | LB | UFA | |
| Trubisky, Mitchell | BUF | QB | UFA | TEN |
| Van Demark, Ryan | BUF | OT | RFA |  MIN |
| VanSumeren, Ben |  PHI | LB | RFA | BUF |
| White, Tre'Davious | BUF | CB | UFA | |
| Wishnowsky, Mitch | BUF | PT | UFA | BUF |
| Zylstra, Shane | DET | TE | UFA | BUF |